A group of Jewish-American soldiers, “The Basterds”, are chosen specially to spread fear throughout the Third Reich by brutally murdering Nazis in France during World War II. They soon cross paths with a French-Jewish teenage girl who manages a Paris movie theatre that has been targeted by the soldiers.

A computer disc containing sensitive CIA material accidentally falls into the hands of a pair of gym workers and they become intent on exploiting their find. Events spiral out of control and cascade into a series of hilariously dark encounters.