Based on the best-selling novel by Jodi Picoult. Anna (Abigail Breslin) is not technically sick, but has undergone countless procedures and surgeries and shots, even though she is only thirteen. Anna was conceived as a “harvest” child, and was genetically engineered to be a bone marrow match for her older sister Kate (Sofia Vassilieva) who suffers from leukaemia. As Anna gets older she begins to challenge her role as the “harvest” child and sues her parents for medical emancipation.

A devastated Dustin (Biggs) finds himself turning to his best friend and rebound advice-giving expert, Tank (Dane Cook) when his girlfriend Alexis (Hudson) tells him they need a break – permanently. Tank is a renowned master with a flawless record when it comes to seducing women, until he tries to work his magic on Alexis. Tank is often hired by recently dumped guys to take their ex-girlfriends out on dates so horrifyingly bad the girls go running back to their relieved beaus. Unexpectedly attracted to Alexis’ headstrong nature, Tank finds himself confronted with a choice between loyalty to Dustin or chasing Alexis.